HCV (CMIA)

Halin cutar hanta na hepatitis C har yanzu ba a san shi ba.Lokacin da HCV ya kwafi a cikin ƙwayoyin hanta, yana haifar da canje-canje a cikin tsari da aikin hanta ko kuma yana tsoma baki tare da haɗin sunadarai na hanta, wanda zai iya haifar da lalacewa da necrosis na ƙwayoyin hanta, yana nuna cewa HCV kai tsaye yana lalata hanta kuma yana taka rawa a cikin pathogenesis.Duk da haka, yawancin masana ilimin lissafi sunyi imanin cewa maganin rigakafi na salula na iya taka muhimmiyar rawa.Sun gano cewa hepatitis C, kamar hepatitis B, yana da yawancin ƙwayoyin CD3+ da ke shiga cikin kyallen jikin ta.Kwayoyin Cytotoxic T (TC) musamman suna kai hari ga sel da aka yi niyya na kamuwa da cutar HCV, wanda zai iya haifar da lalacewar hanta.

RIA ko ELISA

Radioimmunodiagnosis (RIA) ko enzyme-linked immunosorbent assay (ELISA) an yi amfani da shi don gano anti HCV a cikin jini.A cikin 1989, Kuo et al.kafa hanyar radioimmunoassay (RIA) don anti-C-100.Daga baya, Kamfanin Ortho ya sami nasarar haɓaka wani gwajin immunosorbent mai alaƙa da enzyme (ELISA) don gano anti-C-100.Duk hanyoyin biyu suna amfani da yisti da aka bayyana antigen (C-100-3, furotin da NS4 ke ɓoye, mai ɗauke da amino acid 363), bayan tsarkakewa, an rufe shi da ƙananan ramuka na farantin filastik, sannan a saka shi tare da gwajin jini.Sannan ana hada kwayar cutar antigen da anti-C-100 a cikin maganin da aka gwada.A ƙarshe, an ƙara isotope ko enzyme mai lakabin linzamin kwamfuta anti human LGG monoclonal antibody, kuma ana ƙara ma'aunin don tantance launi.